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Emerging and re-emerging diseases caused by tick and mosquito-borne viruses are of public health concern around the world. However, in many countries of the sub-Saharan African region including Ghana, epidemiological and entomological information on these infections are limited, and their prevalence remain largely unknown. In this study, we will conduct surveillance on ticks and mosquitoes to detect medically important tick and mosquito-borne viruses in three study sites in and near Kumasi. It is being anticipated that the study will provide knowledge on viral vector surveillance and prevalence of the various viruses inherent. The study will contribute to an assessment of tick mosquito-borne disease risk to public health in Ghana and the West African sub region, informing policy as a results